Collectively, the work in this thesis suggests that cytokine networks are crucial for maintaining an immunosuppressive microenvironment in cancer.
Cadmium is a toxic metal and common environmental contaminant.
Chronic cadmium exposure results in kidney, bone, reproductive, and immune toxicity as well as cancer.
Furthermore, disrupting key components of these networks can tip the balance in favor of cancer immunosurveillance.^ Immunology|Oncology Chao, Timothy, "Cytokine Networks and Immunosurveillance in Cancer" (2017).
The molecular mechanisms governing T helper (Th) cell differentiation and function have revealed a complex network of transcriptional and protein regulators.